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Glutathione levels can however be depleted by factors such as poor diet, stress, ageing, pollution, alcohol and illness, reducing the bodys resilience to oxidative damage

An intra-articular knee series with 16 patients analysed

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In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)