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Higenamine was also isolated as a racemic mixture
They work by increasing insulin when glucose is high, reducing glucagon, slowing stomach emptying, and promoting a feeling of fullness 7
Quintessence Int
This observation led to a study where GLP-1 was given to obese patients with T2DM and showed improved glycemic control with no side effects, establishing a proof-of-concept for GLP-1 agonists, which over time led to their use in the treatment of T2DM patients [21]
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