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In fact, bumetanide did inhibit insulin secretion from NKCC1 KO islets and impaired glucose tolerance in NKCC1 KO mice (Alshahrani and Di Fulvio, 2012) whereas mice hemizygous for NKCC1 showed improved glucose tolerance associated to increased expression of NKCC2A in islet -cells (Alshahrani et al., 2015)
Recently, it has been demonstrated that L-carnitine supplementation can improve insulin resistance and glucose disposal in insulin-resistant humans and rats [3335]
Mental Health 3 , 354373 (2025)
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