Further research reveals abundant GLP-1 receptor expression on murine small intestinal T cells (129, 130), suggesting that GLP-1 RAs may directly modulate T cells and influence autoimmune responses, potentially delaying diabetes onset and progression
174 Previous studies have reported the comprehensive effects of GLP-1RA on the CNS, which go beyond the levels of blood glucose modulation, but are associated with numerous metabolic aspects such as food intake and preference, 127,175 water intake, 176 energy expenditure, 177 body weight reduction, 178 pancreatic function, 132,179,180 hypertension, 181 stress, 182 addiction behaviors, 183,184 as well as neurodegenerative disorders, such as Alzheimer and Parkinson diseases
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