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Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24% weight loss in phase 2 trials
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It is well understood, extensively studied, and forms the backbone of modern GLP-1 therapy
Another option patients may pursue is to slowly taper off the drugs over about three to six months and to focus on reinforcing lifestyle choices that support goals for overall health and weight maintenance
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