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This protection slows the cascade of damage that leads to dullness, rough texture, and visible signs of photoaging such as uneven tone and surface roughness

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Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)