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Additionally, some patients undergoing rapid weight loss with GLP-1 drugs have shown signs of muscle and bone loss, necessitating further research into long-term effects
Proximity ligation assay technology kit was purchased from Sigma (Santa Clara, CA, USA, DU092101)
The extended-release (ER) formulation encapsulates exenatide within biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres, which form a polymeric matrix that allows sustained drug release following SC administration [13, 14, 58]
The presence of histidine (His) at position 6 and arginine (Arg) at position 7 creates multiple positively charged sites at physiological pH (approximately 7.4)
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