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2022 Mar 7;14(5):1114
Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability
Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)
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