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For some patients, dehydration can lead to acute kidney injury

Common side effects include Genital yeast infections (particularly in women) Urinary tract infections Nasopharyngitis back pain Serious side effects These are less common but require immediate medical attention: Ketoacidosis (a buildup of acids in the blood that can occur even when blood sugar is not very high) Severe kidney infections (pyelonephritis) Necrotizing fasciitis of the perineum (a rare but life-threatening soft tissue infection) Severe allergic reactions

These are systemic effects that berberine also touches through its own mechanisms, which creates both complementarity and the need for careful management