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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)
Handling and Storage Recommendations Store unopened vials at 28 C If frozen storage is used, maintain at 20 C Protect from direct light exposure Avoid moisture contamination during handling Allow vial to equilibrate before reconstitution to reduce condensation After reconstitution, store at 28 C and minimize freezethaw cycles Research Use Only Notice This product is intended for laboratory research use only and is not approved for human or veterinary use
Several biomarkers deserve attention throughout the protocol
The specific form of semaglutide delivered is also not mentioned
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