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Fatigue and Cognitive Impairment First-generation antihistamines (like diphenhydramine/Benadryl and hydroxyzine) are notorious for causing drowsiness because they cross the blood-brain barrier and block H1 receptors in the central nervous system

The third body is in vivo rodent work, largely on muscle, bone, gut and neural tissue, some of it using the LR3 variant specifically because its altered clearance and reduced binding-protein capture change tissue exposure relative to native protein

Tidefelt U, Elmhorn-Rosenborg A, Paul C, Hao XY, Mannervik B, Eriksson LC

Always talk to a doctor to find the best B12 shot for you