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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class

Patients are advised to report any persistent or severe symptoms to their healthcare provider for further management

The Grimace scale was used to assess spontaneous pain, while mechanical and thermal sensitivities were evaluated using Von Frey, Randall-Sellito, hind paw cold allodynia, and hot plate tests

You must be vigilant when taking semaglutide, especially with insulin or insulin secretagogues to avoid severe hypoglycemia