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However, commonly reported consequences of low-fat diets are fatigue and poor appetite control
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44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model
The most common side effects reported include nausea, diarrhea, and constipation
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