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For a plain-language overview of why this buildup happens with weekly dosing, see Medical News Todays explainer

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The gut biome is the collection of enzymes and bacteria that live in your gut

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The tolerable upper intake level for adults is generally set at 4,000 IU daily from supplements, though short-term higher doses under medical supervision are used for correction of deficiency

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Front Pharmacol (2022) 13:926211

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