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The largest cohort study to date, published in JAMA in 2011 (N = 443,198 adults aged 25 to 64), found no increase in the risk of myocardial infarction, sudden cardiac death, or stroke among current users of ADHD stimulants compared to nonusers (adjusted rate ratio 0.83, 95% CI 0.72 to 0.96) [6]

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