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Placebo -Skin and Antioxidant Outcomes A published double-blind RCT showed that oral glutathione supplementation at 500mg/day produced measurable improvements in skin luminosity, reduced melanin index, and increased plasma antioxidant capacity versus placebo at 12 weeks

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a dose adjusted to that employed in humans by means of the application of the body surface area normalization method 71 , frequently used in rodent models 72,73

A notable proportion of patients achieve clinically significant weight loss, with studies indicating that around 40% of adults lost at least 5% of their body weight after one year, and over 15% lost at least 10%