semaglutide stop working Why am I not losing weight on (Ozempic/Wegovy)? GLP-1 drugs such as semaglutide

The molecule itself is a modified form of insulin-like growth factor 1 carrying two deliberate changes that reduce its capture by the IGF binding proteins, which is why it is used as a cell-culture supplement

perhaps a slight testosterone dip or cholesterol change, rather than complete shutdown of hormones

The somatomedin hypothesis which was first proposed in the early 1970s, provided a model for IGF1 actions on the skeleton (see Figure 2 ) elaborated in igf-1 global knockouts, as will be discussed in more detail in a later section, show infertility and profound growth retardation at birth, phenotypes that are not observed in GH- or GH receptor-null animals

Depends on whether theyve been reconstituted or not