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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)
doi: 10.1002/jdn.10155 44 VelazquezRFerreiraEKnowlesSFuxCRodinAWinslowWet al
Pregnant patients exposed to Zepbound and healthcare providers are encouraged to contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979)
It requires no refrigeration and has no restrictions on the timing of food or water intake
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