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They found that people taking Contrave lost around 6% of their body weight after 56 weeks

Time- and dose-related improvements in insulin sensitivity were similar to the temporal patterns of body weight loss with retatrutide in both the MASLD cohort reported here and in the full cohort of people with obesity 13

Selective inhibition in astrocytes alone was sufficient to prevent non-cell-autonomous neuronal loss and prolong survival, as a mechanism of neurodegeneration driven by reactive astrocytes (Smith et al., 2020)