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Endogenous synthesis of Gln under hypoxic conditions was rate-limiting relative to normoxia where only maximal oxygen consumption rate (OCR) was sensitive to GLS inhibition, and inhibition of GLS or glutamine synthetase (GS) reduced basal and maximal OCR (54)

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Discussion BPC 157 has been shown to exert beneficial effects against different pathological conditions [1,2,1026], it induced gastroprotective, analgesic and anti-inflammatory wound healing effects [1,2,1017], also effective against experimental colitis [1016] and showing a particular interaction with the NO-system [14,15,1826]