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While direct, peer-reviewed, head-to-head clinical trials comparing the two forms are still emerging, we can extrapolate a great deal from the known chemical properties

sulindac, a NSAID, which inhibits COX-2 [54] and the anti-diabetic drug pioglitazone, which is an agonist of the peroxisome proliferator-activated receptor gamma with anti-inflammatory effects [55, 56]

Neither subject participants nor those administering the intervention were blinded, though investigators performing MS analyses were blinded to sample identities other than sample identification codes

Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis