Bariatric surgery was modelled as a potential subsequent treatment option for patients not meeting therapeutic goals under non-surgical management, and could occur in either arm, independent of initial assignment (semaglutide 2.4 mg plus D&E or D&E alone), applying Spain-specific eligibility criteria (minimum BMI threshold and maximum age) and a low annual national incidence rate reflecting limited capacity and waiting lists (Table S7)
Pharmaceutical Research, 16(9), 1412-1416
Am J Physiol Legacy Content 67(1):5764
This included treatment-emerging depression, exacerbation of depressive symptoms, fluctuations in depressive mood, and other clinically pertinent depressive-related events expressly covered in the studies.Considering the possible expanded effect of the GLP-1 RAs in mood and the central nervous system, the secondary outcomes were anxiety, mood disorder, suicidal thoughts, and mood-related adverse events.To increase the comparability and exhaustiveness of our analysis and investigate possible mediating variables about psychiatric adverse events, we also released data about metabolic parameters including body weight, BMI, fasting blood glucose, and lipid profiles