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Patients whose condition is driven predominantly by metabolic, microvascular, or inflammatory stress will derive greater benefit from cellular GPx1 mimetics than patients presenting with primary mechanical fluid obstructions or genetic structural anomalies

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IgA nephropathy does not almost always lead to dialysis, with current standard of care (RAAS blockade, SGLT2i, BP control), many patients never reach kidney failure

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doi:10.1161/HYPERTENSIONAHA.109.129924 Ahn CS

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