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(30) The authors hypothesized that the observed increase in MI risk may be related to semaglutides action on the sinoatrial node and its potential to elevate heart rate
Safety Considerations and Side Effects Like all medications, GLP-1 drugs have potential side effects: Common side effects include: Nausea, vomiting, diarrhea (usually improving over time) Constipation Stomach pain or indigestion Injection site reactions (mild redness or itching) Less common but more serious concerns include: Pancreatitis (inflammation of the pancreas) Kidney problems Gastroparesis (stomach paralysis) in rare cases Joint and bone issues like arthritis and tendinitis Researchers found no established link between GLP-1 medications and pancreatitis, pancreatic cancer, or thyroid cancer in large studies with years of follow-up
Nitric oxide production in human endothelial cells stimulated by histamine requires Ca 2+ influx
Another contender to Wegovy is Eli Lillys Zepbound, another GLP-1 receptor agonist for obesity that was welcomed by the FDA in November
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