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In this context, activation of LS neurotensin neurons projecting to the nucleus tuberalis lateralis, located in the posterior hypothalamus, reduces the intake of palatable foods and sweet solutions ( 4 R-positive) that project to and activate the ventral part of the LS also reduce food intake (Xu et al., 2023)

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By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD levels and enhances metabolic activity: NNMT Inhibition: Reduces methylation-driven energy conservation pathways, shifting the body toward increased energy expenditure

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