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Approximately 70% of American adults are obese or overweight, a severe health issue associated with heart disease, stroke, and diabetes, linked to an increased risk of certain types of cancer

Some reports have suggested a potential increase in suicidality risk associated with semaglutide, though the preponderance of current evidence does not indicate a heightened risk ( 13 , 14 )

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Discussion In this study, leveraging non-viral LNPs and the HITI-mediated genome editing method, we engineered a secretion-enabled Exe4 peptide, scExe4, and developed an in vivo scExe4 peptide production reservoir via knock-in into mouse liver cells