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According to The New England Journal of Medicine, early clinical trials show participants achieving up to 24% body weight reduction at the highest studied dose

The majority of RWS conducted in patients initiating incretin-based AOM were retrospective 51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71 and included liraglutide users, while only a few studies investigated semaglutide titrated up to 2.4 mg 65,66,69,70,71 (Tables 1 and 2)