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discovered that RPA1 can undergo crotonylation at K88, K379, and K595, and the RPA1 modified by crotonylation is more likely to bind to damaged single-stranded DNA and HR proteins, thereby promoting DNA damage repair and the survival of tumor cells

Clinical trials suggest that it often takes several weeks to a few months of consistent, daily supplementation before patients notice significant improvements in baseline energy levels, cognitive clarity, and exercise tolerance