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This diverse range of bacteria demonstrates the general applicability of E-mediated lysis to all Gram-negative bacteria, with the caveat that the E-specific lysis cassette must be delivered to the new recipient using a vector that permits precise suppression and induction control of the fatal gene E [56]

Therefore, a potentially promising strategy is to recover, or even enhance the ubiquitination and subsequent degradation of these targets to block tumorigenesis

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