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Rozalina McCoy: So as these drugs were being developed, they were also being tested

Neurochem Int, 2007

The diffused H 2 O 2 can react with ferrous iron, resulting in the formation of highly reactive OH radicals

Role of Mitochondrial Pyruvate Transport in Disease In animal studies, where the transport of pyruvate into the mitochondria via the MPC has been disrupted by gene deletion or by pharmacological inhibition, a beneficial effect is observed at the level of insulin resistance, blood glucose homeostasis, diabetes, and the development of metabolic dysfunction-associated steatohepatitis, MASH (commonly referred to as non-alcoholic steatohepatitis: NASH)