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Fetal metabolism uses sulfation pathways that become saturated, shunting more drug to the toxic pathway
GSTP1 and TNF gene variants and associations between air pollution and incident childhood asthma: The Traffic, Asthma and Genetics (TAG) study...glutathione S-transferase pi gene
prescription meds and some OTC meds (Tylenol) UV radiation, medical X-rays, chemotherapy, electromagnetic fields Alcohol use and abuse Unrelieved stress, poor sleep, and lack of exercise or too strenuous exercise which can produce too many free radicals Poor diet, especially one thats low in vitamins, minerals or antioxidants The natural aging process, which drops cellular glutathione production on average 10% per decade In short, when your body's demand for glutathione outpaces its supply, oxidative stress ramps up and that's when problems start
Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)
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