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Cardiometabolic responses to L-carnitine in obese women with knee osteoarthritis: a randomized, double-blind, placebo-controlled pilot study

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The increased FAO driven by carnitine leads to an increase in intracellular acetyl-CoA levels, which can be transferred to the nucleus for acetylation of histone H3K27, thereby activating GATA3 gene expression and promoting the differentiation of triple-negative breast cancer cells to the luminal cell state [36]