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A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]
"Some patients do remarkably well on semaglutide
EVIDENCE GRADES Lau 2021 Lancet dose-dependent placebo-subtracted weight loss to ~10.8% at 26 weeks
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