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Our laboratory has successfully developed LSC as a cell therapy from initial rodent studies to an ongoing phase 1 clinical trial (NCT04262167) 32

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Through the SH2 domain in the receptor, IGF-IR binds to the SH2 domain of Grb2, which, in turn, complexes with Sos, a guanine nucleotide exchange factor that mediates GDP/GTP exchange in Ras GTPase, and leads to Ras activation

They act as signalling molecules that send messages between cells and tissues to perform specific biological functions such as hormone release, tissue repair, fat metabolism, and muscle growth