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In the EPIC-SR trial, which included subjects who were infected with SARS-CoV-2 Delta (79%) or Omicron (19%) variants, PAXLOVID treatment was associated with a 1.05 log10 copies/mL greater median decline in viral RNA shedding levels in nasopharyngeal samples through Day 5, with similar declines observed in subjects infected with Delta or Omicron variants

Participants in the study saw their heart rates increase from baseline, with the effect being more pronounced at higher doses of the compound

For others, the transition triggers indigestion, acid reflux, nausea, or a sensation of excessive fullness even after small meals