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The primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing hypoglycaemia when used alone Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake GLP-1 receptor agonists are typically administered via subcutaneous injection, with dosing frequencies ranging from once daily to once weekly depending on the specific medication, though oral semaglutide (Rybelsus) is also available

Readers are encouraged to verify all details directly with Joi + Blokes and their healthcare provider before making decisions

In a statement, Zealand CMO David Kendali said that the company is certainly disappointed by the rejection but remains confident in glepaglutide and the evidence supporting its use in short bowel syndrome

While this may include prescribing GLP-1s for some patients, these medications are often a tool to help promote weight loss, but not a solution