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Both medications belong to a class called incretin mimetics, but tirzepatide engages a second hormone pathway that semaglutide does not
Purification of naturally occurring peptides by reversed-phase HPLC
A study found that over 18 months, people with type 2 diabetes who took 15 mg of tirzepatide (the active ingredient in Mounjaro) lost an average of 18% of their body weight, compared to 12.4% for those taking 2.4 mg of semaglutide
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