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If you're losing 1-2 pounds per week at 0.5 mg, there's no need to escalate
Metabolic adaptation is most likely the reason for this plateau [11] rather than poor response or resistance to the medication
In this model we exposed BALB/c mice to Alternaria alternata and treated them with melatonin both at 17:00, since this is a time point that has been found to result in the most severe induction of features of allergic airway pathology (9, 27)
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