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The complex pathophysiology of NASH mandates a holistic approach to treating patients, focusing not only on liver histology but also cardiovascular risk and glycemic control, which has proven to be a high bar ( Table 1 )

Long-term conclusions rely on extrapolation Marie Spreckley, obesity researcher and public health nutritionist at the University of Cambridge in England, who was not involved in the study, cautioned that the papers long-term conclusions rely on modeled projections, rather than observed data, as the follow-up period for stopping treatment with newer medicines is limited to about 12 months

It started with a problem that needed solving for the US military