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Its effects on the body are powerful because it improves how insulin works and helps people eat less
Interestingly, Pycnogenol intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage (71)
More recently, long-acting GLP-1 RAs for obesity have been approved: semaglutide (approved in 2021), resulted in an average weight reduction of around 15% 1214 , and tirzepatide (approved in 2023), demonstrating an average weight reduction of approximately 20% 1517
Its potential for type 2 diabetes treatment has captured attention, as the drugs triple receptor agonists aid in restoring blood glucose levels to normalcy
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