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(EtherPC-1 n = 14 metabolites, EtherPC-2 n = 90 metabolites, EtherPE-1 n = 58 metabolites, EtherPE-2 n = 67 metabolites, FA-1 n = 15 metabolites, FA-2 n = 29 metabolites, PC-1 n = 62 metabolites, PC-2 n = 51 metabolites, PG-1 n = 55 metabolites, PG-2 n = 45 metabolites, TG-1 n = 10 metabolites, TG-2 n = 96 metabolites)
Its not just about convenience
Beside these common features, MI and DCI are indeed different molecules: they belong to two different signal cascades and regulate different biological processes
Notably, based on the results from part 1 of the ESSENCE trial, on 15 August 2025, the FDA approved semaglutide 2.4 mg for the treatment of adults with MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis)
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