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doi: 10.1523/JNEUROSCI.0327-06.2006 93 MarraudinoMCarrilloBBonaldoBLlorenteRCampioliEGarateIet al

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The daily dose most likely to prevent harmful side effects in the general population is known as a Tolerable Upper Intake Level (UL)

[4] While the primary benefits come from metformins ability to lower thyroid antibodies, there is some research that suggests it can result in improved thyroid hormone levels and help to lower TSH