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In the SURPASS-2 trial, Tirzepatide participants experienced substantial reductions in HbA1c levels and body weight compared to those treated with semaglutide
However, studies on the combined treatment of AC3174 and AC170222 for obesity have shown an upregulation of calcitonin receptor-like (Calcrl) gene expression
doi:10.1016/j.bbr.2017.11.015 119
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