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Abbreviations ADC: Corticomedullary difference ADC: Apparent diffusion coefficient ASL: Arterial spin labelling CKD: Chronic kidney disease DKD: Diabetic kidney disease DWI: Diffusion-weighted imaging DWI-MRI: Diffusion-weighted MRI FOV: Field of view GLP-1RA: Glucagon-like peptide-1 receptor agonist Hs-CRP: High-sensitivity C-reactive protein RAAS: Reninangiotensinaldosterone-system ROI: Region of interest SEMPA trial: Effect of Empagliflozin and Semaglutide on Cardio-Renal Target Organ Damage in Patients with Type 2 Diabetes A Randomized Trial SGLT-2I: Sodiumglucose cotransporter 2 inhibitor TE: Echo time TKV: Total kidney volume TLCO: 12-Layer concentric objects TR: Repetition time UACR: Urinary albumin/creatinine ratio References Alicic RZ, Rooney MT, Tuttle KR (2017) Diabetic kidney disease: challenges, progress, and possibilities

Alternative options : If you're using cannabis for symptom management (such as pain, anxiety, or nausea), discuss evidence-based alternatives

Acknowledgements We thank all the patients, investigators, and trial-site staff members who were involved in the conduct of the trial

Orforgliprion caused an average 11% weight loss among overweight and obese people after a year and a half, researchers reported in the New England Journal of Medicine