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Clinical trial results have shown further that two GLP-1 receptor agonists (GLP-1 RAs), exenatide and liraglutide, which are approved for the treatment of hyperglycemia in patients with type 2 diabetes, also produce weight loss in overweight subjects without diabetes

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If either agent is used alongside insulin or a sulfonylurea, the risk of hypoglycaemia is increased and medication doses should be reviewed by a clinician