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Reactive oxygen species (ROS)-triggered wave propagation The most compelling evidence for tissue-scale ferroptotic propagation to date comes from a trigger-wave model established in highly confluent epithelial monolayers, in which localized ferroptotic stress gives rise to self-sustaining oxidative fronts that travel across the culture over distances exceeding 5 mm at a nearly constant velocity of ~5.5 m/min
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However, human evidence remains limited , and BPC-157 is not FDA-approved for clinical use
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