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Certain peptides, like BPC-157, can cross the blood-brain barrier when administered nasally, allowing them to interact with neurotransmitters and reduce inflammation in the nervous system

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Dysesthesia The TRIUMPH-4 trial data revealed a notable safety signal: dysesthesia (abnormal sensations like tingling, burning, or numbness) was reported in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose of retatrutide