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In addition, phosphodiesterase-5 inhibitors (PDE-5i), popular among AAS users, were excluded, although they were thought to increase libido after AAS cessation

Which approach makes more sense depends on individual context and is worth discussing with a practitioner

Figure 2b with colour-coded RMSD between crystal structures was generated using the ColorByRMSD Pymol script ( accessed on 16 June 2022)