The pro-depressant effects of MetSR may be mediated through chronic low-grade inflammation, as evidenced by recent research showing significant mediation (30.8% combined effect) through inflammatory markers including platelets, lymphocytes, neutrophils, C-reactive protein (CRP), leukocytes, and INFLA scores (Qiu et al
CRC, Hoboken Sun K, Zhang Y, DAlessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV (2016) Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
They play a vital role in metabolizing substances like glutathione
In its reduced state, it is "active" and ready to neutralize free radicals