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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
3 In a pre-specified analysis of time to first MACE-5, a composite of all-cause death, heart attack, stroke, heart failure event or coronary revascularization, there were 44 events in the Retatrutide group versus 52 in the placebo group, yielding a hazard ratio of 0.82 (95% CI: 0.55 to 1.22)
Interestingly, the metabolic improvements from significant weight loss (24.2% on average) are typically associated with improvements in fatty liver disease indicators rather than liver stress
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